Skeletal muscle relaxation for ET intubation, during surgery as adjunct to general anesthesia
Child>2 yr: Dose highly individualized; 0.03 mg/kg IV during halothane anesthesia produces blockade in 7 min and lasts 30 min. Under same conditions, 0.05 mg/kg produces blockade in 4 min and lasts 45 min.
Adult: Dose highly individualized: 0.05 mg/kg rapid IV produces conditions for ET intubation in 5 min in about 90% of pts when used as part of thiopental-narcotic induction technique. Lower doses may need longer delay before intubation possible. Neuromuscular blockade lasts about 100 min. Adjust dose to ideal body wt in obese pts ( = 30% ideal wt) to avoid prolonged blockade.
Maintenance of neuromuscular blockade during long procedures
Child = 2 yr, adult:After initial dose 0.05 mg/kg IV, maintenance dose 0.005 and 0.01 mg/kg prolongs neuromuscular blockade for about 30 min and 45 min, respectively. Child usually requires more frequent maintenance doses. Adjust dose to ideal body wt in obese pts ( = 30% ideal wt) to avoid prolonged blockade. |